Development of A Clinically-Oriented Expert System for Differentiating Melanocytic from

Differentiating melanocytic from non-melanocytic (MnM) skin lesions is the first and important step required by clinical experts to automatically diagnosis pigmented skin lesions (PSLs). In this paper, a new clinically-oriented expert system (COE-Deep) is presented for automatic classification of MnM skin lesions through deep-learning algorithms without focusing on preor post-processing steps. For the development of COEDeep system, the convolutional neural network (CNN) model is employed to extract the prominent features from region-ofinterest (ROI) skin images. Afterward, these features are further purified through stack-based autoencoders (SAE) and classified by a softmax linear classifier into categories of melanocytic and non-melanocytic skin lesions. The performance of COE-Deep system is evaluated based on 5200 clinical images dataset obtained from different public and private resources. The significance of COE-Deep system is statistical measured in terms of sensitivity (SE), specificity (SP), accuracy (ACC) and area under the receiver operating curve (AUC) based on 10-fold cross validation test. On average, the 90% of SE, 93% of SP, 91.5% of ACC and 0.92 of AUC values are obtained. It noticed that the results of the COE-Deep system are statistically significant. These experimental results indicate that the proposed COE-Deep system is better than state-of-the-art systems. Hence, the COEDeep system is able to assist dermatologists during the screening process of skin cancer. Keywords—Skin cancer; melanocytic; non-melanocytic; dermoscopy; deep learning; convolutional neural network; stack-